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The qualitative and quantitative impact of biological warfare,
or the threat of such warfare, on military forces and urban
communities has changed markedly in the past 20 years. Improved
production techniques have resulted in more virulent strains of
organisms and the genetic modification of non-pathogenic
organisms to pathogenic strains with virulent characteristics.
The implications of genetic engineering for chemical and
biological warfare are far-reaching. Genetic engineering
provides the potential for improved virulence by the
incorporation of genes (i.e., specific strands of DNA)
permitting increased production of a pathogen or toxin. Thus, as
much as 100 times more pathogen or toxin could be produced per
cell than that which could be produced by naturally occurring
strains. Cells that normally do not produce toxins may be
altered to produce toxins for biological weapon development.
Conversely, known pathogens or toxins may be genetically
inactivated for vaccine countermeasure development. Cells can
also be modified to produce antibodies directly for passive
immunization against specific infectious agents. As with the
human immune system, many current biowarfare detection kits
depend on antibodies reacting with the antigenic surface
coatings of pathogenic bacteria or viruses. Thus, modified
non-pathogens can be used to mask the agent from the
immune-based detector and, potentially, from the human immune
system itself to increase the agent’s effectiveness.
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